Tim Rolvien Selected Research

Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)

1/2020	Enzyme replacement therapy in mice lacking arylsulfatase B targets bone-remodeling cells, but not chondrocytes.
12/2018	The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.

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Tim Rolvien Research Topics

Disease

10	Osteoporosis 12/2022 - 04/2017
6	Pain (Aches) 01/2023 - 11/2016
5	Hypophosphatasia 03/2023 - 08/2019
4	Osteoarthritis 02/2024 - 02/2021
4	Infections 03/2023 - 01/2021
4	Stress Fractures (Stress Fracture) 01/2022 - 01/2018
4	Bone Resorption 07/2019 - 02/2017
3	Metabolic Bone Diseases (Osteopenia) 12/2022 - 10/2019
3	Osteogenesis Imperfecta (Lobstein Disease) 01/2022 - 11/2018
2	Periprosthetic Fractures 01/2024 - 12/2022
2	Rare Diseases (Rare Disease) 03/2023 - 01/2022
2	Arthritis (Polyarthritis) 01/2023 - 01/2022
2	Congenital Abnormalities (Deformity) 01/2023 - 01/2023
2	Wounds and Injuries (Trauma) 01/2023 - 09/2021
2	Neoplasms (Cancer) 04/2022 - 10/2019
2	Embolism (Embolus) 01/2022 - 10/2018
2	Joint Diseases (Joint Disease) 11/2021 - 01/2020
2	Rheumatic Diseases (Rheumatism) 02/2021 - 01/2021
2	Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy) 01/2020 - 12/2018
2	Vitamin D Deficiency 01/2020 - 12/2016
2	Osteolysis 01/2020 - 10/2017
2	Edema (Dropsy) 10/2019 - 08/2019
1	Hemorrhage 02/2024
1	Osteophyte 01/2024
1	Inflammation (Inflammations) 10/2023
1	COVID-19 04/2023
1	Respiratory Insufficiency (Respiratory Failure) 03/2023
1	Hallux Valgus 01/2023
1	Oncogenic osteomalacia 04/2022
1	Hypophosphatemia 04/2022
1	Wasting Syndrome (Wasting Disease) 04/2022
1	Conductive Hearing Loss 01/2022
1	Hypocalcemia 01/2022
1	Musculoskeletal Diseases (Musculoskeletal Disease) 01/2022
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2022
1	Referred Pain 01/2022
1	Coxa Vara 01/2022
1	Coxa Valga 01/2022
1	Mucolipidoses (Sialidosis) 12/2021
1	Rickets (Rachitis) 12/2021
1	Osteoid Osteoma 09/2021
1	Osteochondritis Dissecans 08/2021
1	Sclerosis 06/2020
1	Levin type Osteogenesis imperfecta 06/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	Hemochromatosis (Bronze Diabetes) 01/2020
1	MASS syndrome 01/2019

Drug/Important Bio-Agent (IBA)

7	CalciumIBA 01/2022 - 12/2016
4	Biomarkers (Surrogate Marker)IBA 03/2023 - 02/2017
4	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 03/2023 - 08/2019
3	Proteins (Proteins, Gene)FDA Link 01/2024 - 01/2020
3	EnzymesIBA 03/2023 - 12/2018
3	Alkaline PhosphataseIBA 03/2023 - 10/2019
3	Methotrexate (Mexate)FDA LinkGeneric 01/2022 - 01/2021
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/2023 - 09/2021
2	asfotase alfaIBA 03/2023 - 10/2019
2	Phosphates (Orthophosphate)IBA 04/2022 - 12/2021
2	alpha2 Subunit Collagen Type IIBA 01/2022 - 11/2018
2	GlycosaminoglycansIBA 01/2020 - 12/2018
2	N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA 01/2020 - 12/2018
1	Antifibrinolytic Agents (Antifibrinolytics)IBA 02/2024
1	Tranexamic Acid (AMCA)FDA Link 02/2024
1	Diphosphonates (Bisphosphonates)IBA 01/2024
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2023
1	CoagulaseIBA 01/2023
1	Calcitriol (Calcijex)FDA LinkGeneric 04/2022
1	Somatostatin Receptors (Somatostatin Receptor)IBA 04/2022
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 04/2022
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2022
1	mutalipocin IIIBA 12/2021
1	1,25-dihydroxyvitamin DIBA 12/2021
1	Fibroblast Growth Factor-23IBA 12/2021
1	LigandsIBA 11/2021
1	AnoctaminsIBA 06/2020
1	MineralsIBA 01/2020
1	IronIBA 01/2020
1	GlucocorticoidsIBA 01/2020
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020
1	Cathepsin KIBA 01/2020
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2019
1	Teriparatide (Parathar)FDA Link 08/2019
1	Interleukin-17 (Interleukin 17)IBA 01/2019

Therapy/Procedure

5	Knee Replacement Arthroplasty (Total Knee Replacement) 03/2023 - 02/2021
5	Therapeutics 01/2022 - 11/2016
3	Arthroplasty 01/2022 - 01/2021
2	Operative Surgical Procedures 04/2023 - 01/2021
2	Hip Replacement Arthroplasty (Total Hip Replacement) 01/2022 - 02/2021
1	Personal Protective Equipment 04/2023
1	Enzyme Replacement Therapy 03/2023
1	Arthrodesis 01/2023
1	Minimally Invasive Surgical Procedures 01/2023
1	Orthopedic Procedures 12/2022
1	Decompression 05/2022
1	Diskectomy (Discectomy) 05/2022
1	Prostheses and Implants (Prosthesis) 01/2022
1	Bed Rest (Bedrest) 01/2022
1	Ankle Replacement Arthroplasty 11/2021
1	Conservative Treatment 11/2021
1	Reoperation 08/2021
1	Orthotic Devices (Orthosis) 07/2019